Towards Antitumor Active trans‐Platinum Compounds

Abstract

Substitution of NH₃ by a range of amines in trans‐[PtCl₂(NH₃)₂] produces compounds with cytotoxicity significantly improved over the parent transplatin and in many cases equivalent to that of cisplatin. This microreview summarizes the chemistry and biology of trans‐platinum compounds containing principally planar amines and succinctly reviews the current status of anticancer relevance of the trans‐platinum geometry. The nature of bifunctional DNA adducts (intrastrand, interstrand) is remarkably dependent on the nature of the amine. Further, the stability of monofunctional adducts allows for competitive production of DNA–protein cross‐links and overall the results suggest that the trans‐platinum chemotype may offer significant potential for design of selective DNA–protein cross‐linking agents. A subset of proteins known to bind to DNA modified by trans‐platinum is that comprising zinc fingers – model studies show the potential for formation of heteronuclear thiolate‐bridged species as precedent for zinc displacement from the biomolecule.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)