External forces control mitotic spindle positioning
- 12 June 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 13 (7), 771-778
- https://doi.org/10.1038/ncb2269
Abstract
The cell division axis is determined by the position of the mitotic spindle. How geometrical cues influence spindle orientation is analysed in cells cultured on micropatterns. These experiments show that the mitotic spindle rotates to align with the forces produced by retraction fibres and suggest that forces may be transmitted through a sub-cortical actin structure.Keywords
This publication has 40 references indexed in Scilit:
- Physical Mechanisms Redirecting Cell Polarity and Cell Shape in Fission YeastCurrent Biology, 2008
- Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesisNature, 2008
- Mechanisms of asymmetric cell division: flies and worms pave the wayNature Reviews Molecular Cell Biology, 2008
- The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial PackingCurrent Biology, 2007
- Integrin Signaling Regulates Spindle Orientation in Drosophila to Preserve the Follicular-Epithelium MonolayerCurrent Biology, 2007
- Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent mannerThe EMBO Journal, 2007
- Local force and geometry sensing regulate cell functionsNature Reviews Molecular Cell Biology, 2006
- The extracellular matrix guides the orientation of the cell division axisNature, 2005
- Asymmetric cell divisions promote stratification and differentiation of mammalian skinNature, 2005
- Adherens junctions inhibit asymmetric division in the Drosophila epitheliumNature, 2001