BALB/ Mtv -Null Mice Responding to Strong Mouse Mammary Tumor Virus Superantigens Restrict Mammary Tumorigenesis
- 1 January 2009
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 83 (1), 484-488
- https://doi.org/10.1128/jvi.01374-08
Abstract
The absence of endogenous mouse mammary tumor viruses (MMTVs) in the congenic mouse strain, BALB/ Mtv -null, restricts the early steps of exogenous C3H MMTV infection, preventing the superantigen (Sag) response and mammary tumorigenesis. Here we demonstrate that BALB/ Mtv -null mice also resist tumor induction by FM MMTV, which encodes a stronger Sag compared to C3H MMTV. In contrast to infections with C3H MMTV, Mtv -null mice show FM-MMTV Sag-specific responses comparable to those observed in susceptible BALB/c mice. Neither virus shows significant replication in the spleen or mammary gland. Thus, Mtv -null mice restrict MMTV replication and mammary tumorigenesis even after a robust Sag response.Keywords
This publication has 18 references indexed in Scilit:
- Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo InfectionJournal of Virology, 2007
- Endogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial PathogensPLoS Pathogens, 2006
- The Type B Leukemogenic Virus Truncated Superantigen Is Dispensable for T-Cell LymphomagenesisJournal of Virology, 2003
- Lack of MMTV Superantigen Presentation in MHC Class II-Deficient MiceCellular Immunology, 1996
- The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire.The Journal of Experimental Medicine, 1995
- A Vβ.2‐specific superantigen from exogenous mouse mammary tumor virus carried by FM miceEuropean Journal of Immunology, 1994
- An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7).The Journal of Experimental Medicine, 1992
- Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virusNature, 1991
- A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virusNature, 1991
- The endogenous mouse mammary tumour virus locus Mtv-8 contains a defective envelope geneVirus Research, 1986