Vereinfachte Peptidsynthese mit schutzgruppenfreien Aminosäure-Hydrochloriden nach dem Prinzip der Vierkomponenten-Kondensation

Abstract

Simplified Synthesis of Peptides with Non-protected Amino acid hydrochlorides via Four-Component Condensation Synthesis of sulfur containing peptide analogues, 3-(ω-aminoalkanoyl)-2, 2-dimethyl-1,3-thiazolidine-4-carboxamides 2, via Ugi four-component condensation (4CC) starting from 2,5-dihydro-1,3-thiazoles 1, isocyanides and non-protected amino acid hydrochlorides is described. Involvement of N-phthaloyl amino acids in a typical 4CC and following dephthaloylation of the resulting compounds 2,2-dimethyl-3-(ω-phthalimidoalkanoyl)-1, 3-thiazolidine-4-carboxamides 3, affords peptides 2 in lower overall yields than by the one-step way.