Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
Open Access
- 2 January 2013
- journal article
- Published by Springer Science and Business Media LLC in Nanoscale Research Letters
- Vol. 8 (1), 4
- https://doi.org/10.1186/1556-276x-8-4
Abstract
A near-infrared (NIR)-responsive Aurod@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Aurod@pNIPAAm-PEGMA nanogel were characterized by UV–vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Aurod@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Aurod@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc4) as a drug model. It was also demonstrated that the loaded ZnPc4 could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Aurod@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy.Keywords
This publication has 32 references indexed in Scilit:
- Nanoparticles in Photodynamic TherapyNano Biomedicine and Engineering, 2011
- Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasoundNanoscale, 2011
- In vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled drug deliveryNanomedicine: Nanotechnology, Biology and Medicine, 2010
- Reactive oxygen species produced by irradiation of some phthalocyanine derivativesJournal of Photochemistry and Photobiology A: Chemistry, 2010
- Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardiumBiomaterials, 2009
- Gold Nanorods as Contrast Agents for Biological Imaging: Optical Properties, Surface Conjugation and Photothermal Effects†Photochemistry and Photobiology, 2009
- Light-induced effects in sulfonated aluminum phthalocyanines — potential photosensitizers in the photodynamic therapy: Spectroscopic and kinetic studyJournal of Photochemistry and Photobiology A: Chemistry, 2008
- Gold Nanocages for Biomedical ApplicationsAdvanced Materials, 2007
- Temperature sensitivity of a hydrogel network containing different LCST oligomers grafted to the hydrogel backbonePolymer Gels and Networks, 1998
- Infrared and Raman spectra of 1,5-cyclooctadiene complexes of copper(I), silver(I), gold(I) and gold(III) and the nature of the gold compoundsSpectrochimica Acta Part A: Molecular Spectroscopy, 1973