Preparation, characterization and toxic activity of oxovanadium(IV) mixed-ligand complexes

Abstract

New oxovanadium(IV) mixed-ligand complexes of the general composition [VO(L)(A)], where KHL = potassium salt of salicylideneglycine, A¹ = bis(benzylidene)ethylenediamine, A² = bis (acetophenone)ethylenediamine, A³ = di(2-pyridyl)amine, A⁴ = bis(benzylidene)-1,8-diaminonaphthalene, A⁵ = thiophene-o-carboxaldene-aniline, A⁶ = thiophene-o-carboxaldene-p-anisidine, have been synthesized by the interaction of these ligands with vanadyl sulphate. The mixed-ligand complexes have been characterized on the basis of elemental analysis, magnetic measurements, electronic and infrared spectra. An octahedral structure has tentatively been assigned to all of the mixed-ligand complexes. The mixed-ligand complexes show higher toxic activity against the Salmonella typhi, Escherichia coli and Serratia mercescen as compared to the ligands, vanadyl sulphate and control (dimethyl sulphoxide). The mixed-ligand complexes were also tested against a standard drug (tetracycline).