The Effect of Ultralow-Dose Transdermal Estradiol on Urinary Incontinence in Postmenopausal Women
Open Access
- 1 November 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Obstetrics & Gynecology
- Vol. 106 (5, Part 1), 946-952
- https://doi.org/10.1097/01.aog.0000182576.48290.6d
Abstract
To estimate the effect of 2 years of treatment with ultralow-dose transdermal estradiol (E2) on incontinence in postmenopausal women. Ultra Low Dose Transdermal estRogen Assessment (ULTRA) was a multicenter, randomized, double-blinded, placebo-controlled trial of unopposed ultralow-dose (0.014 mg/d) transdermal E2 for prevention of osteoporosis in 417 postmenopausal women aged 60 to 80 years. Frequency of incontinence episodes was assessed at baseline and after 4 months and 2 years of treatment using a self-reported questionnaire. We used an intention-to-treat analysis to compare change in incontinence frequency, improved (decreased 2 or more episodes per week), unchanged (increased or decreased no more than 1 episode per week), or worsened (increased 2 or more episodes per week) between the E2 and placebo groups among women with and without at least weekly incontinence at baseline. At baseline, the prevalence of at least weekly incontinence was similar between E2 and placebo groups (43%). After 2 years, there was no difference between groups in the proportions of women with incontinence at baseline whose incontinence improved, worsened, or was unchanged. The odds ratio for worsening incontinence in the E2 compared with placebo group was 1.35 (95% confidence interval 0.75-2.42. In women without incontinence at baseline, the odds of developing at least weekly incontinence after 2 years in the E2 compared with placebo group was not significant (odds ratio 1.2, 95% confidence interval 0.7-2.2). Two years of treatment with unopposed ultralow-dose transdermal E2 did not substantially change the frequency of incontinence symptoms or alter the risk of developing at least weekly incontinence. I.Keywords
This publication has 37 references indexed in Scilit:
- Effects of Estrogen With and Without Progestin on Urinary IncontinencePublished by American Medical Association (AMA) ,2005
- Effect of Raloxifene on Urinary IncontinenceObstetrics & Gynecology, 2004
- Oestrogens for urinary incontinence in womenPublished by Wiley ,2003
- The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinenceBJOG: An International Journal of Obstetrics and Gynaecology, 2002
- Uterine effects of 3-year raloxifene therapy in postmenopausal women younger than age 60Obstetrics & Gynecology, 2000
- Paraurethral connective tissue in stress-incontinent women after menopauseActa Obstetricia et Gynecologica Scandinavica, 1998
- Efficacy of estrogen supplementation in the treatment of urinary incontinenceObstetrics & Gynecology, 1996
- Changes in Urethral Cytology following Estrogen AdministrationGynecologic and Obstetric Investigation, 1990
- Treatment with oral piperazine oestrone sulphate for genuine stress incontinence in postmenopausal womenBJOG: An International Journal of Obstetrics and Gynaecology, 1987
- Fatty Acid Composition of Serum Lecithin and Cholesterol Ester in the Normal Menstrual CycleHormone and Metabolic Research, 1985