gp 140, the C3d/EBV receptor (CR2), is phosphorylated upon in vitro activation of human peripheral B lymphocytes
- 3 March 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 197 (1-2), 353-356
- https://doi.org/10.1016/0014-5793(86)80356-8
Abstract
Gp 140, the C3d/EBV receptor (CR2), is a specific marker of human B lymphocytes. Very recent data suggest that CR2 is a membrane site involved in early B cell activation. These properties of CR2 led us to analyze the molecular events associated with gp 140. We analyzed whether in some conditions of B lymphocyte activation, CR2 could be phosphorylated. We have found that when highly enriched peripheral B cells were cultured for 48 h with anti-μ Ab and/or SAC, in order to provide an optimal activating signal, phosphorylation of the CR2 was induced.Keywords
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