Analysis of the Immunogenetic Background of Japanese Leprosy Patients by the HLA System
- 1 May 1982
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 42 (5), 243-247
- https://doi.org/10.1111/j.1423-0410.1982.tb00751.x
Abstract
295 lepromatous and 74 tuberculoid leprosy patients were typed for HLA-A, -B and -C and compared to 110 healthy controls. It was found that frequency of HLA-B7 was significantly high and that of Bw54 was significantly low in lepromatous leprosy. HLA-DR and MT types were investigated in 84 lepromatous and 28 tuberculoid patients and compared to 55 controls. Both lepromatous and tuberculoid patients showed a marked increase in DR2 frequency. The relative risk is 8.7 and 5.9. Lepromatous leprosy showed an increase in frequency of MT1 and decreases in those of DRw9 and MT3 too.Keywords
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