Comparison of Two Third-Generation Parathyroid Hormone Assays
- 1 February 2003
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 49 (2), 336-337
- https://doi.org/10.1373/49.2.336/-a
Abstract
During the last few years, it has been shown that the current intact PTH, or second-generation, assays will cross-react with a large C-terminal fragment, PTH (7–84), which lacks the six N-terminal amino acids (2)(3). Because of the lack of specificity in these second-generation systems, falsely increased PTH values have been observed (3). New third-generation PTH tests do not detect PTH (7–84) and therefore provide a more accurate measurement of bioactive PTH.Keywords
This publication has 4 references indexed in Scilit:
- Human PTH-(7-84) Inhibits Bone Resorption in Vitro Via Actions Independent of the Type 1 PTH/PTHrP ReceptorEndocrinology, 2002
- Vitamin D Status and Redefining Serum Parathyroid Hormone Reference Range in the ElderlyJournal of Clinical Endocrinology & Metabolism, 2001
- Synthetic Carboxyl-Terminal Fragments of Parathyroid Hormone (PTH) Decrease Ionized Calcium Concentration in Rats by Acting on a Receptor Different from the PTH/PTH-Related Peptide ReceptorEndocrinology, 2001
- A Novel Immunoradiometric Assay Detects Full-Length Human PTH but not Amino-Terminally Truncated Fragments: Implications for PTH Measurements in Renal FailureJournal of Clinical Endocrinology & Metabolism, 1999