A Trial-Based Approach to Statin Guidelines
- 18 September 2013
- journal article
- viewpoint
- Published by American Medical Association (AMA) in JAMA
- Vol. 310 (11), 1123-1124
- https://doi.org/10.1001/jama.2013.276529
Abstract
When the last set of US lipid-lowering guidelines was updated in 2004,1 placebo-controlled trials had proven statin therapy to be effective for the secondary prevention of cardiovascular disease. At that time, the ability of these agents to reduce rates of vascular events in primary prevention remained controversial, long-term safety with regard to cancer was unclear, and pharmacologic therapy was relatively expensive.This publication has 4 references indexed in Scilit:
- The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trialsThe Lancet, 2012
- Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-AnalysisDiabetes Care, 2009
- Criteria for Evaluation of Novel Markers of Cardiovascular RiskCirculation, 2009
- Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III GuidelinesCirculation, 2004