Lipoproteins and lipoprotein metabolism in periodontal disease
- 1 June 2010
- journal article
- Published by Taylor & Francis Ltd in Clinical Lipidology
- Vol. 5 (3), 397-411
- https://doi.org/10.2217/clp.10.27
Abstract
A growing body of evidence indicates that the incidence of atherosclerosis is increased in subjects with periodontitis – a chronic infection of the oral cavity. This article summarizes the evidence that suggests periodontitis shifts the lipoprotein profile to be more proatherogenic. LDL-C is elevated in periodontitis and most studies indicate that triglyceride levels are also increased. By contrast, antiatherogenic HDL tends to be low in periodontitis. Periodontal therapy tends to shift lipoprotein levels to a healthier profile and also reduces subclinical indices of atherosclerosis. In summary, periodontal disease alters lipoprotein metabolism in ways that could promote atherosclerosis and cardiovascular disease.Keywords
This publication has 101 references indexed in Scilit:
- Triglycerides as vascular risk factors: new epidemiologic insightsCurrent Opinion in Cardiology, 2009
- Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cellsThrombosis Research, 2009
- Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in miceCardiovascular Research, 2008
- Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart diseaseClinical and Experimental Immunology, 2007
- Periodontal infections cause changes in traditional and novel cardiovascular risk factors: Results from a randomized controlled clinical trialAmerican Heart Journal, 2006
- The effects of periodontal therapy on vascular endothelial function: A pilot trialAmerican Heart Journal, 2006
- Periodontal disease and adverse pregnancy outcomes: a systematic reviewBJOG: An International Journal of Obstetrics and Gynaecology, 2006
- Porphyromonas gingivalis‐induced platelet aggregation in plasma depends on Hgp44 adhesin but not Rgp proteinaseMolecular Microbiology, 2005
- A perspective on the potential cardioprotective benefits of periodontal therapyAmerican Heart Journal, 2005
- Periodontal treatment improves endothelial dysfunction in patients with severe periodontitisAmerican Heart Journal, 2005