Catalytic Asymmetric Three-Component Acyl-Strecker Reaction
- 24 February 2007
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (6), 1149-1151
- https://doi.org/10.1021/ol0702674
Abstract
The first organocatalytic asymmetric three-component Strecker reaction, the urea-catalyzed acylcyanation of in situ generated imines, has been developed. Different α-amido nitriles are formed in excellent yields and enantioslectivities from aldehydes, amines, and acyl cyanides in the presence of Jacobsen's thiourea catalyst 5. Despite its obvious use for the synthesis of α-amino acids and their derivatives, our reaction may find use in diversity oriented synthesis and medicinal chemistry.Keywords
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