Nicolau syndrome: An iatrogenic cutaneous necrosis
Open Access
- 1 January 2009
- journal article
- case report
- Published by Medknow in Journal of Cutaneous and Aesthetic Surgery
- Vol. 2 (2), 92-5
- https://doi.org/10.4103/0974-2077.58523
Abstract
Nicolau syndrome is an uncommon complication of intramuscular injection leading to variable degrees of necrosis of skin and the underlying tissues. We report here two cases of this syndrome. Our first case was a 25 year-old male who developed intense pain and purplish discoloration of the skin in the right hip after intramuscular diclofenac injection. The second case was a 60 year-old male who developed intense pain and discoloration of skin, not only at the injection site, but also on the left scapular area and left elbow after receiving chlorpheniramine maleate injection intramuscularly. These cases highlight the need for awareness about this condition and the need to exercise utmost care during the administration of any parenteral injections by dermatologists.Keywords
This publication has 19 references indexed in Scilit:
- Nicolau syndrome induced by intramuscular vitamin K in a premature newbornEuropean Journal of Pediatrics, 2009
- Nicolau syndrome following intramuscular benzathine penicillinJournal of Postgraduate Medicine, 2008
- SUBJECT INDEXThe Journal of Dermatology, 2007
- Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetateJDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2007
- Nicolau Syndrome following Intramuscular Diclofenac Administration: A Case ReportJournal of Orthopaedic Surgery, 2006
- Nicolau syndrome: a report of 2 cases.2006
- Dermite livédoïde de l'épaule secondaire à une infiltration sous-acromiale répétée d'un corticostéroïdePraxis, 2006
- Nicolau syndrome caused by piroxicamInternational Journal of Dermatology, 2004
- Five cases of livedo‐like dermatitis (Nicolau’s syndrome) due to bismuth salts and various other non‐steroidal anti‐inflammatory drugsJournal of the European Academy of Dermatology and Venereology, 2001
- Embolia cutis medicamentosa of the foot after sclerotherapy.1999