Tools of the trade: psychophysiological interactions and functional connectivity
Top Cited Papers
Open Access
- 7 May 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in Social Cognitive and Affective Neuroscience
- Vol. 7 (5), 604-609
- https://doi.org/10.1093/scan/nss055
Abstract
Psychophysiological interactions (PPIs) analysis is a method for investigating task-specific changes in the relationship between activity in different brain areas, using functional magnetic resonance imaging (fMRI) data. Specifically, PPI analyses identify voxels in which activity is more related to activity in a seed region of interest (seed ROI) in a given psychological context, such as during attention or in the presence of emotive stimuli. In this tutorial, we aim to give a simple conceptual explanation of how PPI analysis works, in order to assist readers in planning and interpreting their own PPI experiments.Keywords
This publication has 20 references indexed in Scilit:
- Temporally-independent functional modes of spontaneous brain activityProceedings of the National Academy of Sciences of the United States of America, 2012
- Social neuroscience: challenges and opportunities in the study of complex behaviorAnnals of the New York Academy of Sciences, 2011
- Correspondence of the brain's functional architecture during activation and restProceedings of the National Academy of Sciences of the United States of America, 2009
- Predicting human resting-state functional connectivity from structural connectivityProceedings of the National Academy of Sciences of the United States of America, 2009
- Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode NetworkCerebral Cortex, 2008
- Consistent resting-state networks across healthy subjectsProceedings of the National Academy of Sciences of the United States of America, 2006
- Fast and robust fixed-point algorithms for independent component analysisIEEE Transactions on Neural Networks, 1999
- Functional connectivity in the motor cortex of resting human brain using echo‐planar mriMagnetic Resonance in Medicine, 1995
- The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations.Journal of Personality and Social Psychology, 1986
- Investigating Causal Relations by Econometric Models and Cross-spectral MethodsEconometrica, 1969