Immunogenicity and Safety of an F-Genotype Attenuated Mumps Vaccine in Healthy 8- to 24-Month-Old Children
- 1 August 2018
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 219 (1), 50-58
- https://doi.org/10.1093/infdis/jiy469
Abstract
Mumps vaccine immunizations have reduced the incidence of this disease. With the variation of mumps circulating strain, novel vaccine strains are always important. A 2-center parallel, randomized, double-blind noninferiority trial was performed to compare an F-genotype attenuated mumps vaccine (SP strain) to the A-genotype vaccine (S-79, Jeryl-Lynn strain) in 1080 healthy children aged 8–24 months in Hubei, China. Participants were randomly assigned to receive a high or low dose of the SP or S79 vaccine and then assessed clinically at 30 minutes and 1–28 days postinoculation. No differences in local or systemic reactivity were observed. A similar incidence of severe adverse events associated with the vaccine was observed in the high-dose group and the positive control group. Based on throat swab collections, no viral shedding was present at the 4th and 10th days in any group. Neutralizing and hemagglutination-inhibiting antibody assays with the F- or A-genotype strains showed similar trends in geometric mean titers in the high-dose SP and S79 groups. Increased cytotoxic T lymphocyte responses were observed in all groups. The F-genotype attenuated mumps vaccine is safe, offers immunogenicity against a homologous virus, and is noninferior to the A-genotype vaccine in 8- to 24-month-old children.Keywords
Funding Information
- State Project for Essential Drug Research and Development of China (2013ZX09101016)
- CAMS Initiative for Innovative Medicine of China (2016-I2M-1-019)
- Yunnan Province Research Program of China (2015ZJ001, 2017ZF020)
- Basic Scientific Research of CAMS in China (2016ZX310180-6)
This publication has 27 references indexed in Scilit:
- Recent Mumps Outbreaks in Vaccinated Populations: No Evidence of Immune EscapeJournal of Virology, 2012
- Identification and development of a promising novel mumps vaccine candidate strainMicrobes and Infection, 2010
- Mumps Outbreaks in Vaccinated Populations: Are Available Mumps Vaccines Effective Enough to Prevent Outbreaks?Clinical Infectious Diseases, 2008
- Recent Resurgence of Mumps in the United StatesThe New England Journal of Medicine, 2008
- Mumps Outbreaks in Canada and the United States: Time for New Thinking on Mumps VaccinesClinical Infectious Diseases, 2007
- Mumps Virus-Specific Antibody Titers from Pre-Vaccine Era Sera: Comparison of the Plaque Reduction Neutralization Assay and Enzyme ImmunoassaysJournal of Clinical Microbiology, 2005
- Mumps and the UK epidemic 2005BMJ, 2005
- Aseptic meningitis as a complication of mumps vaccinationThe Pediatric Infectious Disease Journal, 1991
- The immunizing effect and reactogenicity of two live attenuated mumps virus vaccines in Swedish schoolchildrenJournal of Biological Standardization, 1983
- EVALUATION IN YOUNG CHILDREN OF THE URABE AM 9 STRAIN OF LIVE ATTENUATED MUMPS VACCINE IN COMPARISON WITH THE JERYL LYNN STRAINActa Paediatrica, 1983