In vitro Immunomodulatory activity of verbascoside from Nepeta ucrainica L.
- 17 September 2002
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 16 (6), 593-595
- https://doi.org/10.1002/ptr.990
Abstract
Nepeta ucrainica L. is used as a herbal tea in Kazakhistan. Phytochemical investigations of the aerial parts of the plant resulted in the isolation of verbascoside (1) and 1,5,9-epi-deoxyloganic acid (2). The structures of the compounds were elucidated by spectral (UV, IR, 1H-NMR and 13C-NMR) methods and HPLC analysis. The in vitro immunomodulatory activity of verbascoside was investigated by assessing neutrophil function; chemotaxis and intracellular killing activity. Verbascoside showed an increased chemotactic activity in all doses applied compared with the medium used as a negative control and had a positive effect on respiratory burst of neutrophils, but there was an opposite effect with increasing doses, pointing to a possible suppression of neutrophil intracellular killing activity. Copyright © 2002 John Wiley & Sons, Ltd.Keywords
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