ISARIIN, A NEW DEPSIPEPTIDE FROM ISARIA CRETACEA
- 1 August 1962
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 40 (8), 1579-1584
- https://doi.org/10.1139/v62-239
Abstract
One of the metabolic products of the fungus Isaria cretacea has been found to yield four different amino acids and a hydroxyacid on acid hydrolysis. The amino acids were identified as glycine, L-alanine, L-valine, and D-leucine, and a quantitative analysis showed them to be present in the molar ratio of 1:1:2:1, respectively. The hydroxyacid was identified as D-β-hydroxydodecanoic acid. These units appear to be combined in a simple cyclic structure by means of peptide bonds and an ester linkage between the hydroxyl of hydroxydecanoic acid and the carboxyl of the C-terminal amino acid. The sequence valine → β-hydroxydodecanoic acid → glycine has been established.Keywords
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