Heat stress: a cause of chronic kidney disease along the Mesoamerican west coast?

Abstract

Objectives High incidence of chronic kidney disease (CKD), unrelated to conventional risk factors and anecdotally linked to young male sugarcane workers, occurs along the Pacific coastline, from south-Mexico down to north-Costa Rica. We hypothesise occupational heat stress with chronic dehydration as a major risk factor. Methods We discuss four recent Central American studies, three Nicaraguan and a Salvadorian, as the basis for the heat stress hypothesis. Results All studies observed high prevalences of CKD ≥ stage 3 (glomerular filtration rate Conclusions Harsh and hot work on plantations and in mines in the Pacific lowlands appear related to the Mesoamerican CKD epidemic, possibly through chronic dehydration interacting with other environmental or occupational risk factors. The heat stress hypothesis can be tested measuring heat exposure in different occupations and settings, together with mechanistically sound intermediate outcomes.