Kojiglycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice
- 30 December 2018
- journal article
- research article
- Published by Taylor & Francis Ltd in Bioscience, Biotechnology, and Biochemistry
- Vol. 83 (8), 1514-1522
- https://doi.org/10.1080/09168451.2018.1562877
Abstract
Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed with koji glycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed with koji glycosylceramide. Therefore, it was considered that koji glycosylceramide affects the cholesterol metabolism in obese mice. Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice.Keywords
Funding Information
- Japan Association for Techno-innovation in Agriculture (26056A)
- Japan Association for Techno-innovation in Agriculture (26056A)
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