Mycotoxin co-contamination of food and feed: meta-analysis of publications describing toxicological interactions
- 1 August 2011
- journal article
- review article
- Published by Brill in World Mycotoxin Journal
- Vol. 4 (3), 285-313
- https://doi.org/10.3920/wmj2011.1281
Abstract
Most fungi are able to produce several mycotoxins simultaneously; moreover food and feed can be contaminated by several fungi species at the same time. Thus, humans and animals are generally not exposed to one mycotoxin but to several toxins at the same time. Most of the studies concerning the toxicological effect of mycotoxins have been carried out taking into account only one mycotoxin. In the present review, we analysed 112 reports where laboratory or farm animals were exposed to a combination of mycotoxins, and we determined for each parameter measured the type of interaction that was observed. Most of the published papers concern interactions with aflatoxins and other mycotoxins, especially fumonisins, ochratoxin A and trichothecenes. A few papers also investigated the interaction between ochratoxin A and citrinin, or between different toxins from Fusarium species. Only experiments with a 2×2 factorial design with individual and combined effects of the mycotoxins were selected. Based on the raw published data, we classified the interactions in four different categories: synergistic, additive, less than additive or antagonistic effects. This review highlights the complexity of mycotoxins interactions which varies according to the animal species, the dose of toxins, the length of exposure, but also the parameters measured.Keywords
This publication has 99 references indexed in Scilit:
- Effects of Aflatoxin B1 and Fumonisin B1 on Blood Biochemical Parameters in BroilersToxins, 2010
- Combined Toxic Effects of Ochratoxin A and Citrinin, In Vivo and In VitroPublished by American Chemical Society (ACS) ,2008
- Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits (Oryctolagus cuniculus)Chemico-Biological Interactions, 2007
- Effect in rats of simultaneous prenatal exposure to ochratoxin A and aflatoxin B1. II. Histopathological features of teratological anomalies induced in fetusesBirth Defects Research Part B: Developmental and Reproductive Toxicology, 2004
- Effect in rats of simultaneous prenatal exposure to ochratoxin A and aflatoxin B1. I. Maternal toxicity and fetal malformationsBirth Defects Research Part B: Developmental and Reproductive Toxicology, 2004
- Effect of graded levels of aflatoxin, ochratoxin and their combinations on the performance and immune response of broilersBritish Poultry Science, 2004
- Toxic interaction of fumonisin B1 and fusaric acid measured by injection into fertile chicken eggMycopathologia, 1995
- Individual and combined effects of t‐2 toxin and das in laying hensBritish Poultry Science, 1994
- Effect of aflatoxin B1, ochratoxin a and rubratoxin B on infant ratsFood and Cosmetics Toxicology, 1977
- Ochratoxin A and Citrinin Induced Nephrosis in Beagle Dogs II. PathologyVeterinary Pathology, 1977