Antimalarial Activity of 1,4‐Epidioxy‐bisabola‐2,12‐diene Derivatives
- 1 January 1997
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 330 (1-2), 12-16
- https://doi.org/10.1002/ardp.19973300104
Abstract
1,4-Epidioxy-bisabola-2,12-diene (3) and aromatic hydroperoxides (4, 5) were prepared by photoxidation of γ-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds, 3 and 9, did not show in vivo antimalarial activity in mice.Keywords
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