Trophic Actions of Bone Marrow-Derived Mesenchymal Stromal Cells for Muscle Repair/Regeneration
Open Access
- 17 October 2012
- Vol. 1 (4), 832-850
- https://doi.org/10.3390/cells1040832
Abstract
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) represent the leading candidate cell in tissue engineering and regenerative medicine. These cells can be easily isolated, expanded in vitro and are capable of providing significant functional benefits after implantation in the damaged muscle tissues. Despite their plasticity, the participation of BM-MSCs to new muscle fiber formation is controversial; in fact, emerging evidence indicates that their therapeutic effects occur without signs of long-term tissue engraftment and involve the paracrine secretion of cytokines and growth factors with multiple effects on the injured tissue, including modulation of inflammation and immune reaction, positive extracellular matrix (ECM) remodeling, angiogenesis and protection from apoptosis. Recently, a new role for BM-MSCs in the stimulation of muscle progenitor cells proliferation has been demonstrated, suggesting the potential ability of these cells to influence the fate of local stem cells and augment the endogenous mechanisms of repair/regeneration in the damaged tissues.This publication has 147 references indexed in Scilit:
- Long-term Engraftment of Multipotent Mesenchymal Stromal Cells That Differentiate to Form Myogenic Cells in Dogs With Duchenne Muscular DystrophyMolecular Therapy, 2012
- Heterogeneity in the muscle satellite cell populationSeminars in Cell & Developmental Biology, 2010
- Mesenchymal and haematopoietic stem cells form a unique bone marrow nicheNature, 2010
- Combination of chemokine and angiogenic factor genes and mesenchymal stem cells could enhance angiogenesis and improve cardiac function after acute myocardial infarction in ratsMolecular and Cellular Biochemistry, 2010
- A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial InfarctionJournal of the American College of Cardiology, 2009
- Distinct Origins and Genetic Programs of Head Muscle Satellite CellsDevelopmental Cell, 2009
- Repair of Tissues by Adult Stem/Progenitor Cells (MSCs): Controversies, Myths, and Changing ParadigmsMolecular Therapy, 2009
- Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 productionNature Medicine, 2008
- Cellular and molecular mechanisms of fibrosisThe Journal of Pathology, 2007
- Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftmentBiochemical and Biophysical Research Communications, 2007