Comparison of Topical Anti- Fungal Agents Sertaconazole and Clotrimazole in the Treatment of Tinea Corporis-An Observational Study
Open Access
- 1 January 2014
- journal article
- Published by JCDR Research and Publications in Journal of Clinical and Diagnostic Research
- Vol. 8 (9), HC09-12
- https://doi.org/10.7860/JCDR/2014/10210.4866
Abstract
To compare the efficacy of topical antifungal agents, Sertaconazole and Clotrimazole in Tinea corporis patients. A total of 60(n=60) patients were included in the study. They were divided into two groups of 30 patients each. First group included patients treated with topical Sertaconazole as test drug whereas the second group constituted patients treated with topical Clotrimazole as standard drug. The patients were advised to apply the drug on affected area twice daily for three weeks. The parameters like erythema, scaling, itching, margins and size of the lesion and KOH mount were taken for the assessment of efficacy. This was an open labelled study and patients were followed up every week for three weeks. The total score included all grades in erythema, itching, scaling, margins and size of lesion and KOH mount. There was significant reduction in erythema (p<0.02) and highly significant reduction in scaling (p<0.001), itching (p<0.001) and margins of lesion (p<0.001) among Sertaconazole group. The mean difference and the standard deviation of total scores for Clotrimazole were 7.20 and 1.69 and for Sertaconazole group 8.80 and 1.52 respectively. The p-value on application of students unpaired t- test was p<0.001 (Highly significant). From the present study, it can be concluded that topical Sertaconazole shows better improvement in the clinical parameters than topical Clotrimazole within a span of three weeks in the treatment of T corporis.Keywords
This publication has 10 references indexed in Scilit:
- Emerging fungal infections among children: A review on its clinical manifestations, diagnosis, and preventionJournal of Pharmacy And Bioallied Sciences, 2010
- SertaconazoleDrugs, 2009
- In VitroAntifungal Activity of Sertaconazole Nitrate Against Recent Isolates of Onychomycosis Causative AgentsJournal of Chemotherapy, 2008
- Comparative Study of 2% Sertaconazole Solution and Cream Formulations in Patients with Tinea Corporis, Tinea Pedis Interdigitalis, or a Corresponding CandidosisAmerican Journal of Clinical Dermatology, 2007
- Anti-inflammatory and anti-itch activity of sertaconazole nitrateArchiv für dermatologische Forschung, 2006
- In vitro Antifungal Activity of Sertaconazole Compared with Nine Other Drugs against 250 Clinical Isolates of Dermatophytes and Scopulariopsis brevicaulisChemotherapy, 2004
- Topical Therapy for Fungal InfectionsAmerican Journal of Clinical Dermatology, 2004
- In vitro activity of sertaconazole.1992
- Multi-centre double-blind trial on the efficacy and safety of sertaconazole 2% cream in comparison with miconazole 2% cream on patients suffering from cutaneous mycoses.1992
- In vitro antifungal activity of sertaconazole.1992