The Frequency of Ras Mutations in Cancer
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- 24 March 2020
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 80 (14), 2969-2974
- https://doi.org/10.1158/0008-5472.can-19-3682
Abstract
Ras is frequently mutated in cancer; however, there is a lack of consensus in the literature regarding the cancer mutation frequency of Ras, with quoted values varying from 10-30%. This variability is at least in part due to the selective aggregation of data from different databases and the dominant influence of particular cancer types and particular Ras isoforms within these datasets. In order to provide a more definitive figure for Ras mutation frequency in cancer, we cross-referenced the data in all major publicly accessible cancer mutation databases to determine reliable mutation frequency values for each Ras isoform in all major cancer types. These percentages were then applied to current US cancer incidence statistics to estimate the number of new patients each year that have Ras-mutant cancers. We find that ~19% of cancer patients harbor Ras mutations; equivalent to ~3.4 million new cases per year worldwide. We discuss the Ras isoform and mutation-specific trends evident within the datasets that are relevant to current Ras-targeted therapies.Keywords
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Funding Information
- North West Cancer Research Fund (CR1166)
- National Cancer Institute National Institutes of Health (HHSN261200800001E)
This publication has 57 references indexed in Scilit:
- K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactionsNature, 2013
- NMR-based functional profiling of RASopathies and oncogenic RAS mutationsProceedings of the National Academy of Sciences of the United States of America, 2013
- A Comprehensive Survey of Ras Mutations in CancerCancer Research, 2012
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics DataCancer Discovery, 2012
- Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF KinaseOnline Journal of Public Health Informatics, 2011
- Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesisNature, 2007
- Replacement of K‐Ras with H‐Ras supports normal embryonic development despite inducing cardiovascular pathology in adult miceEMBO Reports, 2005
- Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4aCell, 1997
- Biological and biochemical properties of human rasH genes mutated at codon 61Cell, 1986
- Biological properties of human c-Ha-ras1 genes mutated at codon 12Nature, 1984