The Role of Chemotherapy in Upper Tract Urothelial Carcinoma
Open Access
- 26 January 2009
- journal article
- review article
- Published by Hindawi Limited in Advances in Urology
- Vol. 2009, 1-4
- https://doi.org/10.1155/2009/419028
Abstract
Locally advanced upper tract urothelial carcinoma has a poor prognosis. While surgery represents the only potentially curable therapeutic intervention, recurrences are common and typically systemic in nature. It is thus reasonable to consider perioperative chemotherapy in an effort to decrease the risk of recurrence. There are very little direct data providing clinical guidance in this scenario. For urothelial cancer of the bladder, there are randomized phase III data demonstrating a survival advantage with neoadjuvant cisplatin-based combination chemotherapy. Although arguments favoring adjuvant chemotherapy could be made for upper tract urothelial cancer, the loss of renal function that occurs with nephrectomy can complicate administration of appropriate perioperative treatment. Therefore, by analogy to urothelial carcinoma of the lower tract, it is argued that cisplatin-based neoadjuvant chemotherapy should be the standard of care for patients with locally advanced upper tract urothelial cancer.Keywords
This publication has 52 references indexed in Scilit:
- Neoplasms of the Upper Urinary TractAdvances in Anatomic Pathology, 2008
- Is Routine Urine Cytology Useful in the Haematuria Clinic?The Annals of The Royal College of Surgeons of England, 2008
- Cancer Statistics, 2007CA: A Cancer Journal for Clinicians, 2007
- Molecular Evidence Supporting Field Effect in Urothelial CarcinogenesisClinical Cancer Research, 2005
- ERRATUMJournal of Clinical Oncology, 2004
- Docetaxel and Cisplatin With Granulocyte Colony-Stimulating Factor (G-CSF) Versus MVAC With G-CSF in Advanced Urothelial Carcinoma: A Multicenter, Randomized, Phase III Study From the Hellenic Cooperative Oncology GroupJournal of Clinical Oncology, 2004
- Neoadjuvant Chemotherapy plus Cystectomy Compared with Cystectomy Alone for Locally Advanced Bladder CancerThe New England Journal of Medicine, 2003
- Neoadjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysisThe Lancet, 2003
- Cigarette smoking and bladder cancer in men: A pooled analysis of 11 case-control studiesInternational Journal of Cancer, 2000
- The significance of lymphadenectomy in transitional cell carcinoma of the upper urinary tractBJU International, 1998