In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae)
- 8 August 2008
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 22 (10), 1307-1310
- https://doi.org/10.1002/ptr.2486
Abstract
Seven tetrahydrofuran lignans, isolated from Nectandra megapotamica (Lauraceae), were evaluated for their in vitro antileishmanial and antimalarial activities. Among the evaluated compounds, machilin-G (1a) and veraguensin (2a) showed the highest antileishmanial activities, displaying for both compounds an IC50 value of 18 µg/mL and an IC90 value of 36 µg/mL, while galgravin (1b), nectandrin-A (1c), nectandrin-B (1d), calopeptin (2b) and ganshisandrine (3) were inactive against Leishmania donovani. In the antimalarial assay against Plasmodium falciparum, it was observed that calopeptin (2b) displayed moderate activity, with IC50 values of 3800 ng/mL (D6 clone) and 3900 ng/mL (W2 clone), while the lignans 1a–1d, 2a and 3 were inactive. In order to compare the effect on the parasites with toxicity to mammalian cells, the cytotoxic activity of the isolated compounds were evaluated against the Vero cells, showing that all evaluated tetrahydrofuran lignans exhibited no cytotoxicity at the maximum dose tested. Copyright © 2008 John Wiley & Sons, Ltd.Keywords
This publication has 29 references indexed in Scilit:
- Antifungal Activity of C-27 Steroidal SaponinsAntimicrobial Agents and Chemotherapy, 2006
- Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and ratsJournal of Pharmacy and Pharmacology, 2004
- Analgesic and anti-inflammatory activities evaluation of (-)-O-acetyl, (-)-O-methyl, (-)-O-dimethylethylamine cubebin and their preparation from (-)-cubebinIl Farmaco, 2004
- Tetrahydrofuran Lignans from Nectandra megapotamica with Trypanocidal ActivityJournal of Natural Products, 2003
- In VitroTrypanocidal Activity of Triterpenes fromMiconiaSpeciesPlanta Medica, 2003
- Biological activity evaluation of dibenzilbutirolactones lignans derivatives against Leishmania braziliensisRevista Brasileira de Farmacognosia, 2003
- Evaluation of the Trypanocidal Activity of Lignans Isolated from the Leaves of Zanthoxylum naranjilloPlanta Medica, 1999
- Aporphine Alkaloids of Selected Species ofNectandraandOcoteaPlanta Medica, 1995
- (-)-Grandisin from Cryptocarya crassinerviaJournal of Natural Products, 1991
- Toxicity determined in vitro by morphological alterations and neutral red absorptionToxicology Letters, 1985