Mossy fiber synaptic reorganization in the epileptic human temporal lobe
- 1 September 1989
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 26 (3), 321-330
- https://doi.org/10.1002/ana.410260303
Abstract
The distribution of the mossy fiber synaptic terminals was examined using the Timm histochemical method in surgically excised hippocampus and dentate gyrus from patients who underwent lobectomy of the anterior part of the temporal lobe for refractory partial complex epilepsy. The dentate gyrus of epileptic patients demonstrated intense Timm granules and abundant mossy fiber synaptic terminals in the supragranular region and the inner molecular layer. In contrast, the dentate gyrus of presenescent nonepileptic primates demonstrated no Timm granules in the supragranular region. In nonepileptic senescent primates, occasional very sparse supragranuler Timm granules were observed that were easily distinguished from the dense pattern observed in association with human epilepsy. The results are morphological evidence of mossy fiber synaptic reorganization in the temporal lobe of epileptic humans, and suggest the intriguing possibility that mossy fiber sprouting and synaptic reorganization induced by repeated partial complex seizures may play a role in human epilepsy.This publication has 16 references indexed in Scilit:
- Focal hippocampal lesions induce seizures and long-lasting changes in mossy fiber enkephalin and CCK immunoreactivityPeptides, 1988
- Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional ActivityScience, 1988
- Increased susceptibility to hippocampal and amygdala kindling following intrahippocampal kainic acidExperimental Neurology, 1987
- Cellular Mechanisms of Epilepsy: A Status ReportScience, 1987
- Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4Experimental Neurology, 1986
- Evidence implicating dentate granule cells in development of entorhinal kindlingExperimental Neurology, 1986
- The distribution of Timm's stain in the nonsulphide‐perfused human hippocampal formationJournal of Comparative Neurology, 1984
- Intradentate colchicine retards the development of amygdala kindlingAnnals of Neurology, 1982
- Lesion‐induced sprouting of hippocampal mossy fiber collaterals to the fascia dentata in developing and adult ratsJournal of Comparative Neurology, 1981
- A permanent change in brain function resulting from daily electrical stimulationExperimental Neurology, 1969