LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA
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- 1 October 2004
- journal article
- review article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 43 (42), 13233-13241
- https://doi.org/10.1021/bi0485732
Abstract
Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. LNA oligonucleotides display unprecedented hybridization affinity toward complementary single-stranded RNA and complementary single- or double-stranded DNA. Structural studies have shown that LNA oligonucleotides induce A-type (RNA-like) duplex conformations. The wide applicability of LNA oligonucleotides for gene silencing and their use for research and diagnostic purposes are documented in a number of recent reports, some of which are described herein.Keywords
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