Retention of perfluorochemicals in circulating blood and organs of animals after intravenous injection of their emulsions.

Abstract

To choose a perfluorochemical as a candidate for the artificial erythrocyte or organ perfusate, screening of perfluorochemicals was performed from the standpoints of persistence of them in the circulation and deposition in the body tissues of rabbits, mice and rats. In view of elimination from the body, perfluorodecalin was found to be the most suitable compound among five different perfluorochemicals examined. As for emulsifiers, egg yolk phospholipid was found to be the first choice on account of its ability to sustain perfluorochemicals for an adequate period in the circulation as well as the feasibility for preparing emulsion among the three emulsifiers examined. It was found also that the smaller the particle size of emulsion, the better suited for an artificial erythrocyte of perfusate.