Anionic phospholipids can mediate membrane insertion of the anionic part of a bound peptide
- 21 August 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 370 (3), 189-192
- https://doi.org/10.1016/0014-5793(95)00823-r
Abstract
The effect of anionic lipids on the membrane insertion of a carboxyl group on a specially designed palmitoylated peptide was studied, using tryptophan fluorescence. It is demonstrated that the negatively charged membrane surface of mixed phosphatidylcholine/phosphatidylglycerol small unilamellar vesicles enhances the protonation of the C‐terminal carboxyl group, and the subsequent insertion of that part of the peptide.Keywords
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