Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia
- 1 March 1981
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 290 (5802), 142-143
- https://doi.org/10.1038/290142a0
Abstract
Fanconi's anaemia (FA) is an autosomal recessive disorder characterized by a high frequency of 'spontaneous' chromosomal aberrations and an increased risk of cancer. If, as seems plausible, the microscopically visible chromosomal aberrations in this disorder result from DNA or chromatin damage that would normally be repairable, the questions arise as to which step (or steps) in the repair process is deficient and whether the deficiency is intrinsic or the result of secondary factors. We report here that the frequency of chromosomal aberrations in FA lymphocyte cultures is positively related to oxygen tension and suggest that the site primarily affected by the FA mutation is in the complex system of defence (that is, protection and repair) against the genetic toxicity of oxygen.Keywords
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