Ion channels as novel therapeutic targets in heart failure
- 1 March 2005
- journal article
- review article
- Published by Informa UK Limited in Annals of Medicine
- Vol. 37 (1), 44-54
- https://doi.org/10.1080/07853890510007214
Abstract
Electrophysiological remodeling in heart failure (HF) is characterized by major changes in ion channel function and expression that alter the electrical phenotype and predispose to the development of lethal ventricular tachyarrhythmias. In this article, we provide a review of our current understanding of HF-induced ion channel dysfunction by highlighting changes in potassium and sodium currents, pumps, and exchangers as well as calcium handling proteins. We further relate these changes in ion channel function to abnormalities in impulse generation, conduction, and repolarization with a view towards identifying potentially novel targets for anti‐arrhythmic therapy for this public health epidemic.Keywords
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