Addition of neuA , the Gene Encoding N -Acylneuraminate Cytidylyl Transferase, Increases the Discriminatory Ability of the Consensus Sequence-Based Scheme for Typing Legionella pneumophila Serogroup 1 Strains
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- 1 June 2007
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 45 (6), 1965-1968
- https://doi.org/10.1128/jcm.00261-07
Abstract
The standard sequence-based method for the typing of Legionella pneumophila serogroup 1 strains was extended by using the gspA and neuA alleles. The use of neuA as a seventh allele for typing significantly increased the index of discrimination calculated for a panel of unrelated strains (from 0.932 to 0.963) and subdivided some known large common complexes (e.g., 1,4,3,1,1,1). This modification to the standard method is proposed as the method of choice in the epidemiological investigation of L. pneumophila infections.Keywords
This publication has 21 references indexed in Scilit:
- Variation in the Presence of Neuraminidase Genes among Streptococcus pneumoniae Isolates with Identical Sequence TypesInfection and Immunity, 2006
- Consensus Sequence-Based Scheme for Epidemiological Typing of Clinical and Environmental Isolates ofLegionella pneumophilaJournal of Clinical Microbiology, 2005
- Clinical and Environmental Isolates of Legionella pneumophila Serogroup 1 Cannot Be Distinguished by Sequence Analysis of Two Surface Protein Genes and Three Housekeeping GenesApplied and Environmental Microbiology, 2005
- Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticityNature Genetics, 2004
- Comparative sequence analysis of the icm/dot genes in LegionellaPlasmid, 2004
- A Hospital-Associated Outbreak of Legionnaires' Disease Caused by Legionella pneumophila Serogroup 1 Is Characterized by Stable Genetic Fingerprinting but Variable Monoclonal Antibody PatternsJournal of Clinical Microbiology, 2003
- Pan-European Study on Culture-Proven Legionnaires' Disease: Distribution of Legionella pneumophila Serogroups and Monoclonal SubgroupsEuropean Journal of Clinical Microbiology & Infectious Diseases, 2002
- Legionella and Legionnaires' Disease: 25 Years of InvestigationClinical Microbiology Reviews, 2002
- A multicenter evaluation of genotypic methods for the epidemiologic typing of Legionella pneumophila serogroup 1: results of a pan-European studyClinical Microbiology & Infection, 1999
- Cloning and molecular characterization of a Legionella pneumophila gene induced by intracellular infection and by various in vitro stress conditionsMolecular Microbiology, 1994