Acid-Base characteristics of an asphalt binder, with and without anti-strip additives, were evaluated in this study, focusing on the moisture-induced damage potential of acidic aggregates. The study utilizes the surface free energy (SFE) characteristics as a criterion in this evaluation. One performance graded binder, namely PG 64-22, and two amine-based liquid anti-strip additives, namely AD-Here HP Plus and Redicote E-6, were used. The advancing contact angles were determined using the Dynamic Wilhelmy Plate Method (DWPM). It was found that asphalt binder is acidic in nature. The acid component of surface free energy of PG 64-22 is 2.9 dyne/cm2 whereas, the corresponding base component is 0.4 dyne/cm2. Basic chemical compounds such as amines, in the form of anti-strip additives, are found to reduce the acid component and increase the base component of asphalt binders. In the case of an acidic aggregate and an acidic binder, surface chemistry of Lewis acids and bases does not favor adhesion, and a good bond between an acidic aggregate and an acidic asphalt binder is very difficult to obtain, as previously found by many researchers. With the addition of 0.75% AD-Here HP Plus and 0.75% Redicote E-6 in PG 64-22, the acid component is reduced as much as 67% and 65%, respectively. The corresponding increases in base components are 86% and 105%.