Localization of ro (ss‐a) antigen in the cardiac conduction system
Open Access
- 29 November 1987
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 30 (11), 1232-1238
- https://doi.org/10.1002/art.1780301105
Abstract
The presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.Keywords
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