Prostaglandin Inhibitors in the Treatment of Single-system Langerhans Cell Histiocytosis: Pharmacologic Rationale and Report of Two Cases
- 1 October 2008
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Pediatric Hematology/Oncology
- Vol. 30 (10), 778-780
- https://doi.org/10.1097/mph.0b013e318184e6b3
Abstract
Therapeutic trials have confirmed the efficacy of a number of approaches to the treatment of single-system Langerhans cell histiocytosis (LCH). Not so well studied, but with some pharmacologic rationale and anecdotal reports of clinical success, are prostaglandin inhibitors. We present here a review of the possible mechanism of action of prostaglandin inhibitors in LCH and 2 cases of single-organ, single-site LCH treated with only prostaglandin inhibitors, both with sustained favorable clinical outcomes.Keywords
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