SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor
Open Access
- 7 June 2005
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 129 (6), 791-794
- https://doi.org/10.1111/j.1365-2141.2005.05516.x
Abstract
Myelodysplastic syndrome (MDS) progresses into acute leukaemia with a variable time course. We analysed 45 newly diagnosed patients and found that the expression of the Src homology 2 domain‐containing tyrosine phosphatase 1 (SHP1) had a significant impact on disease severity, progression and overall prognosis. Global or lineage‐specific loss of SHP1 was observed by immunohistochemistry in bone marrow biopsies of MDS patients who progressed rapidly (P = 0·0021) and had shorter survival (P < 0·001). Cox regression analysis demonstrated that SHP1 expression in megakaryocytes had prognostic relevance for time to progression (P = 0·009) and overall survival (P = 0·001).Keywords
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