Diet: Friend or Foe of Enteroendocrine Cells: How It Interacts with Enteroendocrine Cells
- 1 January 2012
- journal article
- review article
- Published by Elsevier BV in Advances in Nutrition: An International Review Journal
- Vol. 3 (1), 8-20
- https://doi.org/10.3945/an.111.000976
Abstract
Gut hormones play a key role in the regulation of food intake, energy expenditure, glucose homeostasis, lipid metabolism, and a wide range of metabolic functions in response to food ingestion. These hormones are altered in metabolic diseases, such as obesity and type 2 diabetes, and are thus proposed to be possible targets for the prevention or treatment of these diseases. It is clear that food composition, macronutrients, and other non-nutrient components as well as the physical properties of food not only modulate the secretion of gut peptides but also modulate transcription and enteroendocrine cell differentiation, which ultimately modifies gut hormone response. The specific mechanisms or sensing machinery that respond to the different components of the diet have been studied for many years; however, over the last few years, new molecular genetic techniques have led to important advances, thereby allowing a deeper understanding of these mechanisms. This review addresses the current knowledge regarding enteroendocrine cells and how diet interacts with this machinery to stimulate and regulate the secretion of gut peptides. The potential for diet interventions as a promising strategy for modulating gut hormone responses to food ingestion and, ultimately, preventing or treating metabolic diseases is being emphasized considering that these diseases are currently a public health burden.Keywords
This publication has 127 references indexed in Scilit:
- Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epitheliumThe Journal of cell biology, 2011
- Molecular mechanisms underlying nutrient detection by incretin-secreting cellsInternational Dairy Journal, 2010
- The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satietyEuropean Journal of Nutrition, 2009
- Nutritional regulation of glucagon‐like peptide‐1 secretionJournal Of Physiology-London, 2009
- Glucose Sensing in L Cells: A Primary Cell StudyCell Metabolism, 2008
- Glucose-Dependent Insulinotropic Polypeptide Enhances Adipocyte Development and Glucose Uptake in Part Through Akt ActivationGastroenterology, 2007
- Taste receptor signaling in the mammalian gutCurrent Opinion in Pharmacology, 2007
- Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1Proceedings of the National Academy of Sciences of the United States of America, 2007
- T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1Proceedings of the National Academy of Sciences of the United States of America, 2007
- Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2Journal Of Physiology-London, 2007