Cruciferous Vegetables, Isothiocyanates, and Prevention of Bladder Cancer
Open Access
- 18 February 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Current Pharmacology Reports
- Vol. 1 (4), 272-282
- https://doi.org/10.1007/s40495-015-0024-z
Abstract
Approximately 80 % of human bladder cancers (BC) are non-muscle invasive when first diagnosed and are usually treated by transurethral tumor resection. But 50–80 % of patients experience cancer recurrence. Agents for prevention of primary BC have yet to be identified. Existing prophylactics against BC recurrence, e.g., Bacillus Calmette-Guerin (BCG), have limited efficacy and utility; they engender significant side effects and require urethral catheterization. Many cruciferous vegetables, rich sources of isothiocyanates (ITCs), are commonly consumed by humans. Many ITCs possess promising chemopreventive activities against BC and its recurrence. Moreover, orally ingested ITCs are selectively delivered to the bladder via urinary excretion. This review is focused on urinary delivery of ITCs to the bladder, their cellular uptake, their chemopreventive activities in preclinical and epidemiological studies that are particularly relevant to prevention of BC recurrence and progression, and their chemopreventive mechanisms in BC cells and tissues.Keywords
This publication has 113 references indexed in Scilit:
- Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathwayMolecular and Cellular Biochemistry, 2012
- Allyl Isothiocyanate Arrests Cancer Cells in Mitosis, and Mitotic Arrest in Turn Leads to Apoptosis via Bcl-2 Protein PhosphorylationOnline Journal of Public Health Informatics, 2011
- Association Between Smoking and Risk of Bladder Cancer Among Men and WomenJAMA, 2011
- Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanateMolecular Carcinogenesis, 2010
- Allyl isothiocyanate as a cancer chemopreventive phytochemicalMolecular Nutrition & Food Research, 2010
- Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by ProteasomesOnline Journal of Public Health Informatics, 2009
- Quantification of Sulforaphane Mercapturic Acid Pathway Conjugates in Human Urine by High-Performance Liquid Chromatography and Isotope-Dilution Tandem Mass SpectrometryChemical Research in Toxicology, 2008
- Covalent Binding to Tubulin by IsothiocyanatesOnline Journal of Public Health Informatics, 2008
- Molecular basis for chemoprevention by sulforaphane: a comprehensive reviewCellular and Molecular Life Sciences, 2007
- Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basisPharmacological Research, 2007