Use of Procalcitonin and C-Reactive Protein to Evaluate Vaccine Efficacy against Pneumonia
Open Access
- 22 February 2005
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLoS Medicine
- Vol. 2 (2), e38
- https://doi.org/10.1371/journal.pmed.0020038
Abstract
Pneumonia remains the leading cause of death in young children. The poor specificity of chest radiographs (CXRs) to diagnose pneumococcal pneumonia may underestimate the efficacy of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia. The efficacy of nine-valent pneumococcal conjugate vaccine among children not infected with HIV (21%; 95% confidence interval, 1%–37%) increased when CXR-confirmed pneumonia was associated with serum C-reactive protein of 120 mg/l (12mg/dl) or more and procalcitonin of 5.0 ng/ml or more (64%; 95% confidence interval, 23%–83%). Similar results were observed in children infected with HIV. C-reactive protein and procalcitonin improve the specificity of CXR to diagnose pneumococcal pneumonia and may be useful for the future evaluation of the effectiveness of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia.Keywords
This publication has 13 references indexed in Scilit:
- Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysisClinical Infectious Diseases, 2004
- A role for Streptococcus pneumoniae in virus-associated pneumoniaNature Medicine, 2004
- Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trialThe Lancet, 2004
- A Trial of a 9-Valent Pneumococcal Conjugate Vaccine in Children with and Those without HIV InfectionNew England Journal of Medicine, 2003
- Serum procalcitonin in pneumococcal pneumonia in childrenEuropean Respiratory Journal, 2001
- Procalcitonin in children admitted to hospital with community acquired pneumoniaArchives of Disease in Childhood, 2001
- Reappraisal of Lung Tap: Review of an Old Method for Better Etiologic Diagnosis of Childhood PneumoniaClinical Infectious Diseases, 2001
- Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infectionsThe Pediatric Infectious Disease Journal, 1999
- Accuracy of Radiographic Differentiation of Bacterial from Nonbacterial PneumoniaClinical Pediatrics, 1989
- Pneumonia in childhood.1988