Morphosynthesis of Alanine Mesocrystals by pH Control
- 16 May 2006
- journal article
- Published by American Chemical Society (ACS) in The Journal of Physical Chemistry B
- Vol. 110 (22), 10822-10828
- https://doi.org/10.1021/jp0574807
Abstract
Crystallization of DL-alanine is studied as a single polymorph model case to analyze the different modes of crystallization of polar organic molecules in absence of any structure directing additives. Depending on supersaturation, which is controlled either by temperature or by pH, and in the absence of additives, crystallization by mesoscale assembly of nanoparticles is found over a wide range of conditions, leading to so-called mesocrystals. This supplements the classical molecule-based crystallization mechanism, which is identified at lower supersaturations and at pH values away from the isoelectric point (IEP). The resulting alanine crystals are characterized by SEM, XRD, and single-crystal analysis. Time-resolved conductivity measurements and dynamic light scattering of the reaction solutions reveal information about precursor structures and reaction kinetics. A formation mechanism is proposed for the alanine mesocrystals.Keywords
This publication has 20 references indexed in Scilit:
- Mesocrystals: Inorganic Superstructures Made by Highly Parallel Crystallization and Controlled AlignmentAngewandte Chemie-International Edition, 2005
- Crystalline, Porous Microspheres Made from Amino Acids by Using Polymer‐Induced Liquid Precursor PhasesAngewandte Chemie-International Edition, 2005
- Impact of Molecular Speciation on Crystal Nucleation in Polymorphic Systems: The Conundrum of γ Glycine and Molecular ‘Self Poisoning'Journal of the American Chemical Society, 2004
- Modified genetic algorithm to model crystal structures: III. Determination of crystal structures allowing simultaneous molecular geometry relaxationInternational Journal of Quantum Chemistry, 2003
- Higher‐Order Organization by Mesoscale Self‐Assembly and Transformation of Hybrid NanostructuresAngewandte Chemie-International Edition, 2003
- Precipitation of Self-Organized Copper Oxalate Polycrystalline Particles in the Presence of Hydroxypropylmethylcellulose (HPMC): Control of MorphologyJournal of Colloid and Interface Science, 2000
- Computer Simulation of Crystallization from SolutionJournal of the American Chemical Society, 1998
- Biomimetic Growth and Self‐Assembly of Fluorapatite Aggregates by Diffusion into Denatured Collagen MatricesAngewandte Chemie-International Edition, 1996
- Twinned Crystals of Enantiomorphous Morphology of Racemic Alanine Induced by Optically Resolved .alpha.-Amino Acids; A Stereochemical Probe for the Early Stages of Crystal NucleationChemistry of Materials, 1994
- Dynamics of two-dimensional self-aggregation: pressure and pH-induced structural changes in a fluorocarbon amphiphile at liquid-air interfaces. An x-ray synchrotron studyJournal of the American Chemical Society, 1990