Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism.
- 1 March 1995
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 95 (3), 1071-1077
- https://doi.org/10.1172/JCI117753
Abstract
Serum concentrations of specific cartilage and bone molecules reflecting tissue turnover were measured in two well-defined patient groups with early rheumatoid arthritis with distinctly different disease outcome to see if early differences in their levels are prognostic of the rate of joint destruction. Compared with a matched normal population, increased concentrations of cartilage oligomeric matrix protein (COMP) were found in all patients who developed rapid hip joint destruction. In contrast, levels of a putative marker of cartilage aggrecan synthesis, the chondroitin sulfate epitope 846, were increased only in patients with slow joint destruction. Levels of bone sialoprotein (BSP) were increased in both groups, as were levels of the C-propeptide of type II procollagen (CPII), a marker of collagen II synthesis. The increased concentrations of the 846 epitope in patients with slow joint destruction suggest increased aggrecan synthesis. The low levels of the 846 epitope in patients with rapid joint destruction, concomitant with elevated levels of CPII, suggest a selective increase in collagen synthesis. The elevated BSP levels indicate an increased bone turnover in both groups. Thus elevated serum levels of COMP may indicate an unfavorable prognosis for rapid joint destruction, whereas elevated 846 epitope indicates a more favorable prognosis.This publication has 31 references indexed in Scilit:
- Faculty Opinions recommendation of Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.Published by H1 Connect ,2013
- BODY FLUID MARKERS OF CARTILAGE CHANGES IN OSTEOARTHRITISRheumatic Disease Clinics of North America, 1993
- Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure.Online Journal of Public Health Informatics, 1992
- Serum concentrations of hyaluronan and proteoglycan in joint disease. Lack of association.1991
- Serum hyaluronate level as a predictor of radiologic progression in early rheumatoid arthritisArthritis & Rheumatism, 1991
- Molecular markers of processes in cartilage in joint disease.1991
- Early rheumatoid arthritis —onset, course, and outcome over 2 yearsRheumatology International, 1990
- Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the Blood Markers Hyaluronic Acid, Orosomucoid, and Keratan SulfateArthritis & Rheumatism, 1990
- Rheumatoid ArthritisThe New England Journal of Medicine, 1990
- Structure and biology of cartilage and bone matrix noncollagenous macromoleculesThe FASEB Journal, 1989