Caffeine, Urinary Calcium, Calcium Metabolism and Bone
- 1 September 1993
- journal article
- review article
- Published by Elsevier BV in Journal of Nutrition
- Vol. 123 (9), 1611-1614
- https://doi.org/10.1093/jn/123.9.1611
Abstract
Oral doses of caffeine increase the urinary excretion of calcium, magnesium, sodium and chloride for at least 3 h after consumption. The hypercalciuric effect can be blocked by adenosine receptor agonists. The effect is proportional to dose per lean body mass and no adaptation to the urinary losses occurs with continuing consumption of caffeine. Uncompensated losses of calcium would be a risk factor for development of osteoporosis. Risks of osteoporosis due to caffeine consumption are reviewed. Comparison of data from epidemiological surveys and animal and human studies suggests that for younger adult women consuming adequate calcium, moderate caffeine intakes may have little or no deleterious effects. Increased urinary and intestinal losses may be compensated for by increased intestinal calcium absorption. However older women do not seem to compensate adequately to maintain their former calcium balance, especially when calcium intakes are below recommendations.Keywords
This publication has 25 references indexed in Scilit:
- Is caffeine consumption a risk factor for osteoporosis?Journal of Bone and Mineral Research, 1992
- No effects of adaptation to dietary caffeine on calcium excretion in young womenNutrition Research, 1990
- Effect of prostaglandin inhibition on caffeine-induced hypercalciuria in healthy womenThe Journal of Nutritional Biochemistry, 1990
- Effects of dietary caffeine on renal handling of minerals in adult womenLife Sciences, 1990
- The effect of adenosine and adenosine analogues on methylxanthine-induced hypercaliuria in the ratCanadian Journal of Physiology and Pharmacology, 1989
- Nonalcoholic carbonated beverage consumption and bone fractures among women former college athletesJournal of Orthopaedic Research, 1989
- DIETARY CALCIUM AND RISK OF HIP FRACTURE: 14-YEAR PROSPECTIVE POPULATION STUDYThe Lancet, 1988
- Mineral metabolism and bone strength of rats fed coffee and decaffeinated coffeeJournal of Agricultural and Food Chemistry, 1987
- Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult ratsJournal of Bone and Mineral Research, 1986
- The effect of dietary caffeine on urinary excretion of calcium, magnesium, sodium and potassium in healthy young femalesNutrition Research, 1984