Lipid levels do not influence the risk of venous thromboembolism
- 1 January 2012
- journal article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 108 (11), 923-929
- https://doi.org/10.1160/th12-06-0426
Abstract
Studies on the association between lipid profile and venous thromboembolism (VTE) are inconsistent. This could be caused by classical lipoproteins being inferior to apolipoproteins as markers for VTE risk. Therefore, we examined whether apolipoproteins are more strongly related to VTE than lipoproteins. For this analysis we used the PREVEND prospective community based observational cohort study. Levels of apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), total cholesterol (TC), high-density lipoprotein (HDL), non-HDL, low-density lipoprotein (LDL), triglycerides (TG), lipoprotein(a), ApoB/ApoA1 and TC/HDL ratio were assessed. Subjects with VTE were identified using databases of the national registries of hospital discharge diagnoses, death certificates, and the regional anticoagulation clinic. Out of 7,627 subjects, 110 developed VTE during a median follow-up of 10.5 years. In both univariate and multivariable analyses no significant associations between apolipoproteins and overall VTE were observed. Of the classical lipoproteins, TC, non-HDL, LDL, TG, and TC/HDL ratio were significantly associated with overall VTE in univariate analysis. Significant associations were no longer present in multivariable analysis. TGL and LDL were significantly associated with unprovoked VTE in univariate analysis. After adjustment for age and sex this significance was lost. No significant associations between (apo-) lipoproteins and provoked VTE were found. We conclude that apolipoproteins are not better in predicting VTE risk than the classical lipoproteins. Our population-based cohort study does not show an association between both apolipoproteins and the classical lipoproteins and VTE risk.Funding Information
- Dutch Kidney Foundation
This publication has 37 references indexed in Scilit:
- Risk Factors for Venous ThromboembolismCirculation, 2010
- Incidence of arterial cardiovascular events after venous thromboembolism: a systematic review and a meta-analysisJournal of Thrombosis and Haemostasis, 2010
- Major Lipids, Apolipoproteins, and Risk of Vascular DiseaseJAMA, 2009
- Diet and incident venous thromboembolism: The Iowa Women's Health StudyAmerican Heart Journal, 2009
- The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controlsEuropean Heart Journal, 2009
- A Randomized Trial of Rosuvastatin in the Prevention of Venous ThromboembolismThe New England Journal of Medicine, 2009
- Lipid biomarkers, hormone therapy and the risk of venous thromboembolism in womenJournal of Thrombosis and Haemostasis, 2009
- High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE)Blood, 2008
- Greater Fish, Fruit, and Vegetable Intakes Are Related to Lower Incidence of Venous ThromboembolismCirculation, 2007
- Incidence of arterial cardiovascular events in patients with idiopathic venous thromboembolismThrombosis and Haemostasis, 2006