Is Our Self Nothing but Reward? Neuronal Overlap and Distinction between Reward and Personal Relevance and Its Relation to Human Personality
Open Access
- 24 December 2009
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 4 (12), e8429
- https://doi.org/10.1371/journal.pone.0008429
Abstract
The attribution of personal relevance, i.e. relating internal and external stimuli to establish a sense of belonging, is a common phenomenon in daily life. Although previous research demonstrated a relationship between reward and personal relevance, their exact neuronal relationship including the impact of personality traits remains unclear. Using functional magnetic resonance imaging, we applied an experimental paradigm that allowed us to explore the neural response evoked by reward and the attribution of personal relevance separately. We observed different brain regions previously reported to be active during reward and personal relevance, including the bilateral caudate nucleus and the pregenual anterior cingulate cortex (PACC). Additional analysis revealed activations in the right and left insula specific for the attribution of personal relevance. Furthermore, our results demonstrate a negative correlation between signal changes in both the PACC and the left anterior insula during the attribution of low personal relevance and the personality dimension novelty seeking. While a set of subcortical and cortical regions including the PACC is commonly involved in reward and personal relevance, other regions like the bilateral anterior insula were recruited specifically during personal relevance. Based on our correlation between novelty seeking and signal changes in both regions during personal relevance, we assume that the neuronal response to personally relevant stimuli is dependent on the personality trait novelty seeking.Keywords
This publication has 73 references indexed in Scilit:
- Circular analysis in systems neuroscience: the dangers of double dippingNature Neuroscience, 2009
- Activation of Anterior Insula during Self-ReflectionPLOS ONE, 2009
- How do you feel — now? The anterior insula and human awarenessNature Reviews Neuroscience, 2009
- Connectivity-based segregation of the human striatum predicts personality characteristicsNature Neuroscience, 2008
- Novelty seeking modulates medial prefrontal activity during the anticipation of emotional stimuliPsychiatry Research: Neuroimaging, 2008
- Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics—A fMRI studyHuman Brain Mapping, 2008
- Striatal Activity Underlies Novelty-Based Choice in HumansNeuron, 2008
- Neural systems connecting interoceptive awareness and feelingsHuman Brain Mapping, 2006
- Awareness of the Functioning of One's Own Limbs Mediated by the Insular Cortex?Journal of Neuroscience, 2005
- Event-Related fMRI: Characterizing Differential ResponsesNeuroImage, 1998