Quantitative analysis of regional airways obstruction using dynamic hyperpolarized 3He MRI—Preliminary results in children with cystic fibrosis
Open Access
- 15 August 2005
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 22 (3), 420-426
- https://doi.org/10.1002/jmri.20402
Abstract
Purpose To investigate regional airways obstruction in patients with cystic fibrosis (CF) with quantitative analysis of dynamic hyperpolarized (HP) 3He MRI. Materials and Methods Dynamic radial projection MRI of HP 3He gas was used to study respiratory dynamics in a group of eight children with CF. Signal kinetics in a total of seven regions of interest (ROIs; three in each lung, and one in the trachea) were compared with the results of spirometric pulmonary function tests (PFTs). The tracheal signal intensity was used as a form of “input function” to normalize for input flow effects. Results A pattern of low flow rate in the upper lobes was observed. When the flow measurements from the peripheral ROIs were averaged to obtain an index of flow in the peripheral lung, a good correlation was found (P = 3.74 × 10−5) with the forced expired volume in one second (FEV1). Conclusion These results suggest that a quantitative measurement of localized airways obstruction in the early stages of CF may be obtained from dynamic 3He MRI by using the slope of the signal rise as a measure of air flow into the peripheral lung. This study also demonstrates that children can cooperate well with the 3He MRI technique. J. Magn. Reson. Imaging 2005.Keywords
This publication has 21 references indexed in Scilit:
- Dynamic radial projection MRI of inhaled hyperpolarized 3He gasMagnetic Resonance in Medicine, 2003
- Dynamic spiral MRI of pulmonary gas flow using hyperpolarized 3He: Preliminary studies in healthy and diseased lungsMagnetic Resonance in Medicine, 2001
- Dynamic imaging of hyperpolarized3He distribution in rat lungs using interleaved-spiral scansNMR in Biomedicine, 2000
- Ultraschnelle MRT der Lungenventilation mittels hochpolarisiertem Helium-3*RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 2000
- Cystic Fibrosis: Combined Hyperpolarized3He-enhanced and Conventional Proton MR Imaging in the Lung—Preliminary ObservationsRadiology, 1999
- Rapid imaging of hyperpolarized gas using EPIMagnetic Resonance in Medicine, 1999
- Signal Dynamics in Magnetic Resonance Imaging of the Lung with Hyperpolarized Noble GasesJournal of Magnetic Resonance, 1998
- Pathogenesis of cystic fibrosisThe Lancet, 1993
- MR imaging of lung parenchyma: a solution to susceptibility.Radiology, 1992
- Cystic fibrosis in the United Kingdom 1977-85: an improving picture. British Paediatric Association Working Party on Cystic Fibrosis.BMJ, 1988