Efficiency of translation initiation by non-AUG codons in Saccharomyces cerevisiae.
Open Access
- 1 October 1988
- journal article
- Published by Informa UK Limited in Molecular and Cellular Biology
- Vol. 8 (10), 4533-4536
- https://doi.org/10.1128/mcb.8.10.4533
Abstract
The quantitative levels of initiation of protein synthesis at codons other than AUG were determined with a CYC7-lacZ fused gene in the yeast Saccharomyces cerevisiae. AUG was the only codon which efficiently initiated translation, although some non-AUG codons allowed initiation at very low efficiency, below 1% of the normal level. Since translation initiates at codons other than AUG in at least two wild-type genes from eucaryotes, other factors presumably play a role in enhancing the activity of non-AUG codons.Keywords
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