Predictors of 30-Day Mortality and 90-Day Functional Recovery after Primary Intracerebral Hemorrhage : Hospital Based Multivariate Analysis in 585 Patients
Open Access
- 1 January 2009
- journal article
- Published by Korean Neurosurgical Society in Journal of Korean Neurosurgical Society
- Vol. 45 (6), 341-349
- https://doi.org/10.3340/jkns.2009.45.6.341
Abstract
The purpose of this study was to identify independent predictors of mortality and functional recovery in patients with primary intracerebral hemorrhage (PICH) and to improve functional outcome in these patients.Data were collected retrospectively on 585 patients with supratentorial PICH admitted to the Stroke Unit at our hospital between 1st January 2004 and the 31st July 2008. Using multivariate logistic regression analysis, the associations between all selected variables and 30-day mortality and 90-day functional recoveries after PICH was evaluated.Ninety-day functional recovery was achieved in 29.1% of the 585 patients and 30-day mortality in 15.9%. Age (OR=7.384, p=0.000), limb weakness (OR=6.927, p=0.000), and hematoma volume (OR=5.293, p=0.000) were found to be powerful predictors of 90-day functional recovery. Furthermore, initial consciousness (OR=3.013, p=0.014) hematoma location (lobar, OR=2.653, p=0.003), ventricular extension of blood (OR=2.077, p=0.013), leukocytosis (OR=2.048, p=0.008), alcohol intake (drinker, OR=1.927, p=0.023), and increased serum aminotransferase (OR=1.892, p=0.035) were found to be independent predictors of 90-day functional recovery after PICH. On the other hand, a pupillary abnormality (OR=4.532, p=0.000) and initial unconsciousness (OR=3.362, p=0.000) were found to be independent predictors of 30-day mortality after PICH.The predictors of mortality and functional recovery after PICH identified during this analysis may assist during clinical decision-making, when advising patients or family members about the prognosis of PICH and when planning intervention trials.Keywords
This publication has 47 references indexed in Scilit:
- Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and WomenStroke, 2008
- Recent Epidemiological Trends of StrokeJournal of Korean Neurosurgical Society, 2008
- High Blood Pressure in Acute Stroke and Subsequent OutcomeHypertension, 2004
- Use of the Original, Modified, or New Intracerebral Hemorrhage Score to Predict Mortality and Morbidity After Intracerebral HemorrhageStroke, 2003
- Primary intracerebral haemorrhage in the Jyvaskyla region, central Finland, 1985-89: incidence, case fatality rate, and functional outcome.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Death and functional outcome after spontaneous intracerebral hemorrhage. A prospective study of 166 cases using multivariate analysis.Stroke, 1991
- Ethanol and the Nervous SystemNew England Journal of Medicine, 1989
- Prediction of intracerebral hemorrhage survivalAnnals of Neurology, 1988
- Interobserver agreement for the assessment of handicap in stroke patients.Stroke, 1988
- Hypertensive putaminal hemorrhage: treatment and results. Is surgical treatment superior to conservative one?Stroke, 1983