Impact of Fasting Glycemia and Regional Cerebral Perfusion in Diabetic Subjects

Abstract

Background and Purpose— Diabetes mellitus increases the risk of ischemic stroke. The aim of this study was to investigate the correlation between fasting plasma glucose (FPG) and changes in regional cerebral perfusion (CP) in subjects with DM. Methods— CP was assessed in 24 subjects (mean age 44±2.5 years) with type 1 diabetes mellitus by single photon emission computed tomography. Results— Analysis of CP during elevated FPG (224±24 mg/dL) showed 3 or more deficits in 42% of the subjects. A positive relationship between the number of CP deficits and FPG was observed ( P P P Conclusions— The present study demonstrates that changes in FPG are associated with functional changes in regional CP. Hyperglycemia-induced endothelial dysfunction may be implicated in the impaired regional CP of diabetic subjects.